Adverse Drug Reaction Among HIV Seropositive and HIV Seronegative Adult Pulmonary Tuberculosis Patients.
EDITION:
NJGP Vol 7 No 4
AUTHOR(S):
Dr Salami A K, Dr Oluboyo P O & Dr Akande A A
DATE PUBLISHED:
2008-09-01
ARTICLE:
INTRODUCTION
In recent years there has been a worldwide increase in the incidence of tuberculosis1. This has been attributed largely to the epidemic of Human immune-deficiency virus infection1. The clinical response of majority of these patients to anti-tuberculosis drugs is quite good2, however, a few of them experiences adverse effects of these drugs2. This is mild in most cases; it could be life threatening in a few other instances3. A number of studies have implicated both thiacetazone and streptomycin as the most common cause of severe cutaneous hypersensitivity reactions in patients co-infected with HIV /PTB4,5. Others have compared thiacetazone-containing anti-TB regimen with rifampicin-containing regimen among PTB/HIV infected patients6,7. This study aim at determining the risk factors and the rate of adverse drug reactions between both HIV sero-positive and sero-negative PTB patients treated with thiacetazone free anti-TB drugs.